The novel nootropic compound DM232 (UNIFIRAM) ameliorates memory impairment in mice and rats
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Kisspeptin-13 ameliorates memory impairment induced by streptozotocin in male rats via cholinergic system
Introduction: Kisspeptin-13 (KP-13) is a novel endogenous factor, increases synaptic transmission and is involved in several behavioral functions such as anxiety, locomotion, epilepsy and avoidance learning. However, the role of this peptide on cognition has not been well clarified yet. Here we studied the effect of kisspeptin-13 pretreatment on spatial learning and also interaction with cholin...
متن کاملOvariectomy ameliorates dextromethorphan - induced memory impairment in young female rats
We have previously found that dextromethorphan (DM), over-the-counter cough suppressant, impairs memory retention in water maze task, when it is repeatedly administrated to adolescent female rats at high doses. In this study we examined first if ovariectomy ameliorates the DM-induced memory impairment in female rats, and then whether or not the DM effect is revived by estrogen replacement in ov...
متن کاملPhellodendron amurense and Its Major Alkaloid Compound, Berberine Ameliorates Scopolamine-Induced Neuronal Impairment and Memory Dysfunction in Rats
We examine whether Phellodendron amurense (PA) and its major alkaloid compound, berberine (BER), improved memory defects caused by administering scopolamine in rats. Effects of PA and BER on the acetylcholinergic system and pro-inflammatory cytokines in the hippocampus were also investigated. Male rats were administered daily doses for 14 days of PA (100 and 200 mg/kg, i.p.) and BER (20 mg/kg, ...
متن کاملkisspeptin-13 ameliorates memory impairment induced by streptozotocin in male rats via cholinergic system
introduction: kisspeptin-13 (kp-13) is a novel endogenous factor, increases synaptic transmission and is involved in several behavioral functions such as anxiety, locomotion, epilepsy and avoidance learning. however, the role of this peptide on cognition has not been well clarified yet. here we studied the effect of kisspeptin-13 pretreatment on spatial learning and also interaction with cholin...
متن کاملAuraptene consolidates memory, reverses scopolamine-disrupted memory in passive avoidance task, and ameliorates retention deficits in mice
Objective(s): Auraptene (7-geranyloxycoumarin) (AUR), from Citrus species has shown anti-inflammatory, neuroprotective, and acetylcholinesterase (AChE) and beta-secretase inhibitory effects. Scopolamine is a nonselective muscarinic receptor antagonist which causes short-term memory impairments and is used for inducing animal model of Alzheimer’s disease (AD). This research aimed to investigate ...
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ژورنال
عنوان ژورنال: Drug Development Research
سال: 2002
ISSN: 0272-4391,1098-2299
DOI: 10.1002/ddr.10055